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A new phosphorus binder that retains high binding capacity even when incorporated into breadsticks was well accepted and tolerated by patients with chronic renal failure.Įmploi d'un nouveau chélateur du phosphore dans l'insuffisance rénale chronique. When aluminum carbonate gel, however, was incorporated into breadsticks, its capacity to bind phosphorus was greatly reduced. Moreover, balance studies in patients with chronic renal failure indicated that this experimental binder incorporated into breadsticks is as effective as the best available phosphorus binder (aluminum carbonate gel, Basaljel®). Studies in dialysis patients clearly demonstrated that hyperphosphatemia can be easily corrected. Metabolic studies in which oxygen consumption was determined in cortical renal slices suggested that a decrease in oxygen consumption was due to phosphate deficiency and not to the binder itself. Toxicologic studies performed in rats indicated that the animals ingesting this experimental binder did not show increased aluminum concentration in the brain. This material (Controphos TM) was incorporated into breadsticks in order to increase patient tolerance. We have prepared a new phosphorus binder, an aluminum oxide-based gel, with an increased anion binding capacity. Most of these binders are aluminum-containing preparations designed to be used as antacids and, as such, were not optimized for high anion binding capacity. Thus, phosphorus-binding gels have been prescribed to control phosphorus absorption from the gastrointestinal tract.
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Unfortunately, there are no nutritionally complete, palatable, low-phosphorus diets. The role of phosphorus retention in the development of secondary hyperparathyroidism in renal failure is well established. Use of a new phosphate binder in chronic renal insufficiency.